Alexey Isaev was born in the village of Serebryanye Prudy (Moscow Oblast). He was an assistant camera operator at Tsentrnauchfilm (1978–1979), a member of the Studio of Eccentric Peculiarities (1993–1994), and a staff member of the NeuroVideoCenter of the Burdenko Neurosurgery Institute of the Russian Academy of Medical Sciences (1994–1995). In 2000, together with Olga Shishko, he founded the Moscow information and research center MediaArtLab. In the same year he became the initiator and curator of the annual international symposium Pro&Contra and director of the Media Forum program of Moscow International Film Festival. He created the international online festival Trash‑Art (1999) and was a curator and jury member of the Russian Internet art resources festival Da‑Da‑Net (2000). He was the organizer and curator of the International Festival of Experimental Video, Computer Animation, and Projective Synthesis (Moscow, 1994). In 1995 his solo exhibition Neuromancero took place at Ptyuch video gallery (Moscow). In 1996, together with the philosopher Valery Podoroga, he created the project Eisenstein Pavilion for Manifesta 1 (Rotterdam).
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